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mitotane will decrease the level or effect of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with sturdy CYP3A4 inducers reduces plasma focus of abemaciclib and its metabolites.duvelisib will raise the degree or outcome of abemaciclib by influencing hepatic/inte